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Myths about weight loss medications

“medications are the easy way out”

There’s nothing easy about obesity or its treatment. You still need to watch what you eat, be mindful of getting adequate sleep and physical activity and manage your stress levels while on medications. These medications can help cut down on food noise, cravings for food and alcohol, help you feel full and stay full longer and reduce your hunger. Some people may need more than one medication, and others may not have an adequate response to medications, and we will discuss if your condition warrants a referral for surgical intervention. On average, patients on semaglutide had about 15% weight loss and patients on tirzepatide had about 20% weight loss. Other medications have more modest average weight loss: phentermine (5-7%), Metformin (3-5%), Qsymia (5-11%), Contrave (5-7%), and Liraglutide (7-8%).

 These weight loss medications address biological drivers—like insulin resistance, hunger hormones, and appetite regulation—that willpower alone can't fix. They’re tools, not shortcuts. Obesity is a complex disease. As a disease, much like diabetes or hypertension, medications improve health outcomes more so than diet and exercise alone.

“They’re dangerous and we don’t know the long term side effects”

All medications carry risks, but the newer generation (like semaglutide, tirzepatide) has solid safety data and is FDA-approved. Side effects are typically mild and manageable when started and escalated appropriately by a trained clinician.

Some may believe weight loss medications are dangerous and this comes from misinformation in the media, historic problems with older weight loss medications, misuse, improper prescribing, and the unregulated proliferation of non-FDA approved compounded versions of these medications.

In fact, GLP-1 receptor agonists were first FDA approved in 2005 (Byetta/exenatide) to treat type II diabetes. Next in the 2010’s, liraglutide (Victoza) was introduced, and later Saxenda became the first GLP-1 medication approved for the treatment of obesity in 2014 with modest results.

In 2021, the game changer semaglutide came along when the FDA approved Wegovy for weight loss (Ozempic for type II diabetes) when it showed a 15% average body weight loss.

Finally in 2022, a dual GIP/GLP-1 receptor agonist, tirzepatide (Mounjaro/Zepbound) has taken weight loss to even higher levels (~20%+). Mounjaro was approved for diabetes in 2022, and Zepbound for obesity in 2023.